Hair Dye Use May Increase Bladder Cancer Risk
By Dr. Manuela Gago-Dominguez, Keck School of Medicine

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Women who hide their natural hair color with regular applications of permanent hair dye may be putting themselves at increased risk for bladder cancer, new research findings suggest.

"Our study is the first to demonstrate a frequency- and duration-dependent association between personal use of permanent hair-dyes and bladder cancer risk," lead study author Dr. Manuela Gago-Dominguez, from the Keck School of Medicine at the University of Southern California, told Reuters Health.

To investigate the relationship between permanent hair dyes and bladder cancer, Dr. Gago-Dominguez and colleagues analyzed more than 1500 cases of bladder cancer, 897 of which yielded information about hair dye use. Data on a similar number of adults who did not use permanent hair dye were used for comparison. The study findings will be published in the February, 2001 issue of the International Journal of Cancer.

After adjusting for cigarette smoking, the authors found that women who used permanent hair dye at least once a month were 2 times more likely to develop bladder cancer than women who did not use permanent hair dye. Women who reported regular long-term use of the hair dye for at least 15 years were more than 3 times more likely to develop bladder cancer than non-users.

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Hairstylists and barbers were 50% more likely to have bladder cancer than those who did not have occupational exposure to hair dye. Those who were exposed to hair dye for at least 10 years were five times more likely than the comparison group of unexposed individuals to develop bladder cancer.

"Our novel observations are provocative and carry enormous public health implications," Dr. Gago-Dominguez said. "It is [perhaps] a little premature to make any recommendation about stopping the use of permanent hair dyes," she acknowledged. "However, this is one of the largest and most comprehensive studies ever conducted on the issue and we think our results should not be ignored."

Editor's Note: Please note that the study was limited to bladder cancers leaving the real possibility that hair dyes may be implicated in additional forms of cancer and other health problems

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